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Dr. Daniel E Weeks, PhD

Professor, Human Genetics

Professor, Biostatistics

Contact

Public Health 3119, 130 DeSoto Street, Pittsburgh, PA 15261
R-znvy: jrrxf@cvgg.rqh
Primary Phone: 967-179-0833
Fax: 967-179-8575
Web site:


Personal Statement

Dr. Weeks' research focuses on statistical human genetics in the area of mapping susceptibility loci involved in complex diseases. His primary interest is developing new mapping methods, which involves developing algorithms and statistics, implementing them in computer programs, and testing them on real and simulated data. In addition, he is actively involved in a large number of collaborative disease gene mapping projects, all of which constantly challenge him to develop new and more useful methods for dealing with the complexities of real data. These diseases include age-related macular degeneration, obesity, asthma, food allergy, and biliary atresia.  In addition, he and his
colleagues are studying the effects of methylation on risk for childhood asthma, pre-eclampsia, and on patient outcomes after aneurysmal subarachnoid hemorrhage and traumatic brain injury.


Education

1983         B.A., summa cum laude, Biology and Mathematics, Colby College, Waterville, ME

1983-84   Graduate studies in Applied Mathematics, Rutgers University, New Brunswick, NJ
1985         M.S., Biomathematics, University of California, Los Angeles
1988         Ph.D., Biomathematics (Kenneth Lange, mentor), University of California, Los Angeles
1989-90    Postdoctoral training (Jurg Ott, mentor), Columbia University, New York, NY

Fellowships:
1982       Research Training Program, The Jackson Laboratory, Bar Harbor, ME (David E. Harrison, mentor)
1983       Summer Student Fellow, Woods Hole Oceanographic Institution, MA (Hal Caswell, mentor)
1986-87  Genetic Mechanisms Training Program, UCLA
1987-88  Systems and Integrative Biology Training Program, UCLA
1989-90  Postdoctoral Fellow with Jurg Ott, Ph.D., Columbia University


Teaching


Academic Appointments

1989-90   Research Scientist, New York State Psychiatric Institute
1990-96   Assistant Professor of Human Genetics (tenure-track), University of Pittsburgh
1994-98   Head of Statistical Genetics - Methods, Wellcome Trust Centre for Human Genetics, University of Oxford
1996-02   Associate Professor of Human Genetics (tenured), University of Pittsburgh
2002-03   Associate Professor of Biostatistics (joint appointment), University of Pittsburgh
2004        Acting Chair, Department of Human Genetics
2005        Acting Vice Chair, Department of Human Genetics
2002-       Professor of Human Genetics (tenured), University of Pittsburgh
2003-       Professor of Biostatistics (joint appointment), University of Pittsburgh


Selected Publications

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Orcid ID

Recent publications (from more than 193 peer-reviewed manuscripts)
Last updated June 12, 2018 - use the links above for up-to-date information.

†Graduate student; ‡Post-doctoral trainee.

  

1.       Chiu CY, Jung J, Chen W, Weeks DE, Ren H, Boehnke M, Amos CI, Liu A, Mills JL, Ting Lee ML, Xiong M, Fan R (2017) Meta-analysis of quantitative pleiotropic traits for next-generation sequencing with multivariate functional linear models. Eur J Hum Genet 25:350-359. PMC5315507

2.       Chiu CY, Jung J, Wang Y, Weeks DE, Wilson AF, Bailey-Wilson JE, Amos CI, Mills JL, Boehnke M, Xiong M, Fan R (2017) A comparison study of multivariate fixed models and Gene Association with Multiple Traits (GAMuT) for next-generation sequencing. Genet Epidemiol 41:18-34. PMC5154843

 3.      Ding Y, Liu Y, Yan Q, Fritsche LG, Cook RJ, Clemons T, Ratnapriya R, Klein ML, Abecasis GR, Swaroop A, Chew EY, Weeks DE, Chen W (2017) Bivariate Analysis of Age-Related Macular Degeneration Progression Using Genetic Risk Scores. Genetics 206:119-133. PMC5419464

4.      Grassmann F, Kiel C, Zimmermann ME, Gorski M, Grassmann V, Stark K, International AMD Genomics Consortium (including Weeks DE), Heid IM, Weber BH (2017) Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits. Genome Med 9:29. PMC5368911  

5.      Hong X, Hao K, Ji H, Peng S, Sherwood B, Di Narzo A, Tsai HJ, Liu X, Burd I, Wang G, Ji Y, Caruso D, Mao G, Bartell TR, Zhang Z, Pearson C, Heffner L, Cerda S, Beaty TH, Fallin MD, Lee-Parritz A, Zuckerman B, Weeks DE, Wang X (2017) Genome-wide approach identifies a novel gene-maternal pre-pregnancy BMI interaction on preterm birth. Nat Commun 8:15608. PMC5472707

6.      Persad PJ, Heid IM, Weeks DE, Baird PN, de Jong EK, Haines JL, Pericak-Vance MA, Scott WK, International Age-Related Macular Degeneration Genomics C (2017) Joint Analysis of Nuclear and Mitochondrial Variants in Age-Related Macular Degeneration Identifies Novel Loci TRPM1 and ABHD2/RLBP1. Invest Ophthalmol Vis Sci 58:4027-4038. PMC5559178 

7.      Shan Y†, Tromp G, Kuivaniemi H, Smelser DT, Verma SS, Ritchie MD, Elmore JR, Carey DJ, Conley YP, Gorin MB, Weeks DE (2017) Genetic risk models: Influence of model size on risk estimates and precision. Genet Epidemiol 41:282-296.  PMC5628612 

8.      Govil M, Mukhopadhyay N, Weeks DE, Feingold E, Shaffer JR, Levy SM, Vieira AR, Slayton RL, McNeil DW, Weyant RJ, Crout RJ, Marazita ML (2018) Novel caries loci in children and adults implicated by genome-wide analysis of families. BMC Oral Health 18:98

9.      Krishnan M, Major TJ, Topless RK, Dewes O, Yu L, Thompson JMD, McCowan L, de Zoysa J, Stamp LK, Dalbeth N, Harre Hindmarsh J, Rapana N, Deka R, Eng WWH†, Weeks DE, Minster RL, McGarvey ST, Viali S, Naseri T, Sefuiva Reupena M, Wilcox P, Grattan D, Shepherd PR, Shelling AN, Murphy R, Merriman TR (2018) Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Maori and Pacific (Polynesian) people living in Aotearoa/New Zealand. Diabetologia (Epub ahead of print)

10.    Liu X, Hong X, Tsai HJ, Mestan KK, Shi M, Kefi A, Hao K, Chen Q, Wang G, Caruso D, Geng H, Gao Y, He J, Kumar R, Wang H, Yu Y, Bartell T, Tan XD, Schleimer RP, Weeks DE, Pongracic JA, Wang X (2018) Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy. Medicine (Baltimore) 97:e0043. PMCID: PMC5851764

11.    Yan Q, Ding Y, Liu Y, Sun T, Fritsche LG, Clemons T, Ratnapriya R, Klein ML, Cook RJ, Liu Y, Fan R, Wei L, Abecasis GR, Swaroop A, Chew EY, Group AR, Weeks DE, Chen W (2018) Genome-wide analysis of disease progression in age-related macular degeneration. Hum Mol Genet 27:929-940




 

Daniel E Weeks
© 2018 by University of Pittsburgh Graduate School of Public Health

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