EOH Journal Club Seminar - Fall 2017
Date: Thursday November 16, 2017
Time: 11am - 12pm
Presenter: Brandy Hill
Paper: Traffic-Related Air Pollution and Telomere Length in Children and Adolescents Living in Fresno, CA: A Pilot Study
Authors: Eunice Y. Lee, MS, Jue Lin, PhD, Elizabeth M. Noth, PhD, S. Katharine Hammond, PhD, Kari C. Nadeau, MD, PhD, Ellen A. Eisen, ScD, and John R. Balmes, MD
Objective: The main objective of this pilot study was to gather preliminary information about how telomere length (TL) varies in relation to exposure to polycyclic aromatic hydrocarbons (PAHs) in children living in a highly
Methods: We conducted a cross-sectional study of children living in Fresno, California (n¼14). Subjects with and without asthma were selected based on their annual average PAH level in the 12-months prior to their blood draw. We measured relative telomere length from peripheral blood mononuclear cells (PBMC).
Results: We found an inverse linear relationship between average PAH level and TL (R2¼0.69), as well as between age and TL (R2¼0.21). Asthmatics had shorter mean telomere length than non-asthmatics (TLasthmatic¼1.13, TLnon-asthmatic¼1.29).
Conclusions: These preliminary findings suggest that exposure to ambient PAH may play a role in telomere shortening.
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