EOH Journal Club

EOH Journal Club - Fall 2017 - Qiao Lin

Thursday 10/12 11:00AM - 12:00PM
Bridgeside Point - 339
EOH Journal Club Seminar - Fall 2017

Date: Thursday October 12, 2017

Time: 11am - 12pm

Presenter: Qiao Lin

Paper:  Metabolic co-dependence gives rise to collective oscillations within biofilms

Authors: Liu J, Prindle A, Humphries J, Gabalda-Sagarra M, Asally M, Lee DY, Ly S, Garcia-Ojalvo J, Süel GM

Abstract: Cells that reside within a community can cooperate and also compete with each other for resources. It remains unclear how these opposing interactions are resolved at the population level. Here we investigate such an internal conflict within a microbial (Bacillus subtilis) biofilm community: cells in the biofilm periphery not only protect interior cells from external attack but also starve them through nutrient consumption. We discover that this conflict between protection and starvation is resolved through emergence of long-range metabolic co-dependence between peripheral and interior cells. As a result, biofilm growth halts periodically, increasing nutrient availability for the sheltered interior cells. We show that this collective oscillation in biofilm growth benefits the community in the event of a chemical attack. These findings indicate that oscillations support population-level conflict resolution by coordinating competing metabolic demands in space and time, suggesting new strategies to control biofilm growth.

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Last Updated On Monday, October 02, 2017 by Orbell, Adam W
Created On Monday, October 02, 2017