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Biostatistics Dissertation Defenses

Biostatistics Dissertations

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Events that appear on this page are in the Sponsoring Department of "Biostatistics" with "Dissertation Defenses" as its Category.

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Upcoming

Biostatistics Dissertation Defense

Song Zhang: Diagnostic Accuracy Analysis for Ordinal Competing Risks Outcomes Using ROC Surface

Wednesday 12/6 12:00PM - 2:00PM
Public Health 7139

Song Zhang of the Department of Biostatistics defends her dissertation on "Diagnostic Accuracy Analysis for Ordinal Competing Risks Outcomes Using ROC Surface".



Graduate faculty of the University and all other interested parties are invited to attend


ABSTRACT:

Many medical conditions are marked by a sequence of events or statuses that are associated with continuous changes in some biomarkers.  However, few works have evaluated the overall accuracy of a biomarker in separating various competing events. Existing methods usually focus on a single cause and compare it with the event-free controls at each time.  In our study, we extend the concept of ROC surface and the associated volume under the ROC surface (VUS) from multi-category outcomes to ordinal competing risks outcomes. We propose two methods to estimate the VUS. One views VUS as a numerical metric of correct classification probabilities representing the distributions of the diagnostic marker given the subjects who have experienced different cause-specific events. The other measures the concordance between the marker and the sequential competing outcomes.  Since data are often subject to lost of follow up, inverse probability of censoring weight is introduced to handle the missing  disease status due to independent censoring.  Asymptotic results are derived using counting process techniques and U-statistics theory.  Practical performances of the proposed estimators in finite samples are evaluated through simulation studies and the procedure of the methods are illustrated in two real data examples.

Public Health Significance: ROC curve has long been treated as a gold standard in assessing the accuracy of continuous predictors to binary outcomes.  Our proposed methods extend its utilization to multi-category events outcomes in the presence of competing risks censoring, as well as independent censoring. Our methods aim to assess a global accuracy of a biomarker's predictive power to each of events simultaneously, especially, to which stages of disease progression that patients would land by a specific time in follow-up. 


Last Updated On Monday, November 20, 2017 by Valenti, Renee Nerozzi
Created On Monday, October 23, 2017

Previous

Tue 8/8/2017
Zhaowen Sun: Power and Sample Size Determinations in Dynamic Risk Prediction Biostatistics Dissertation Defense
Zhaowen Sun: Power and Sample Size Determinations in Dynamic Risk Prediction
Tue 8/8/2017 10:00AM - 12:00PM
Public Health 7139

Zhaowen Sun of the Department of Biostatistics defends her dissertation on "Power and Sample Size Determinations in Dynamic Risk Prediction".

Fri 7/28/2017
Yi Liu: Novel Test Procedures for Large-scale Bivariate Time-to-event Data on Single and... Biostatistics Dissertation Defense
Yi Liu: Novel Test Procedures for Large-scale Bivariate Time-to-event Data on Single and...
Fri 7/28/2017 1:00PM - 3:00PM
Public Health 7139

Yi Liu of the Department of Biostatistics defends her dissertation on "Novel Test Procedures for Large-scale Bivariate Time-to-event Data on Single and Gene-based Markers, with an Application to a Genetic Study of AMD Progression"

Tue 7/18/2017
Yimeng Liu: Efficient Estimation of the Quantile Residual Lifetime Using Auxiliary Covariates Biostatistics Dissertation Defense
Yimeng Liu: Efficient Estimation of the Quantile Residual Lifetime Using Auxiliary Covariates
Tue 7/18/2017 10:30AM - 1:00PM
Public Health A522

Alice Liu of the Department of Biostatistics defends her dissertation on "Efficient Estimation of the Quantile Residual Lifetime Using Auxiliary Covariates"
Mon 7/17/2017
Judah Abberbock: Usage of Surrogate Endpoints in the Design and Analysis of Clinical Trials Biostatistics Dissertation Defense
Judah Abberbock: Usage of Surrogate Endpoints in the Design and Analysis of Clinical Trials
Mon 7/17/2017 2:00PM - 4:00PM
Public Health 7139

Judah Abberbock of the Department of Biostatistics defends his dissertation on "Usage of Surrogate Endpoints in the Design and Analysis of Clinical Trials"
Fri 5/5/2017
Abraham Apfel: "A Stability Analysis of Sparse K-means" Biostatistics Dissertation Defense
Abraham Apfel: "A Stability Analysis of Sparse K-means"
Fri 5/5/2017 9:00AM - 11:00AM
Public Health 7139

Abraham Apfel of the Department of Biostatistics defends his dissertation on "A Stability Analysis of Sparse K-means"
Fri 4/14/2017
Chien-Wei Lin: "Power calculation and study design in RNA-Seq and Methyl-Seq" Biostatistics Dissertation Defense
Chien-Wei Lin: "Power calculation and study design in RNA-Seq and Methyl-Seq"
Fri 4/14/2017 3:00PM - 5:00PM
Public Health 7139

Chien-Wei Lin of the Department of Biostatistics defends his dissertation on "Power calculation and study design in RNA-Seq and Methyl-Seq"
Thu 4/13/2017
Yuvika Paliwal: "Generalized Linear Mixed Models for Analysis of Cross-correlated Binary Data in..." Biostatistics Dissertation Defense
Yuvika Paliwal: "Generalized Linear Mixed Models for Analysis of Cross-correlated Binary Data in..."
Thu 4/13/2017 10:00AM - 12:00PM
Public Health 4140

Yuvika Paliwal of the Department of Biostatistics defends her dissertation on "Generalized Linear Mixed Models for Analysis of Cross-correlated Binary Data in Multi-reader Studies of Diagnostic Imaging"
Mon 4/10/2017
Shannon Woolley: "Tests for Random Signs Censoring in Competing Risks" Biostatistics Dissertation Defense
Shannon Woolley: "Tests for Random Signs Censoring in Competing Risks"
Mon 4/10/2017 2:00PM - 4:00PM
Public Health 7139

Shannon Woolley of the Department of Biostatistics defends her dissertation on "Tests for Random Signs Censoring in Competing Risks"

Wed 4/5/2017
Lauren Balmert: "Nonparametric and Semiparametric Inference on Quantile Lost Lifespan" Biostatistics Dissertation Defense
Lauren Balmert: "Nonparametric and Semiparametric Inference on Quantile Lost Lifespan"
Wed 4/5/2017 12:00PM - 2:00PM
Public Health A216

Lauren Balmert of the Department of Biostatistics defends her dissertation on "Nonparametric and Semiparametric Inference on Quantile Lost Lifespan"
Thu 3/30/2017
Zhiguang Huo: "Statistical Integrative Omics Methods for Disease Subtype Discovery" Biostatistics Dissertation Defense
Zhiguang Huo: "Statistical Integrative Omics Methods for Disease Subtype Discovery"
Thu 3/30/2017 1:00PM - 3:00PM
Public Health 7139


Zhiguang Huo of the Department of Biostatistics defends his dissertation on "Statistical Integrative Omics Methods for Disease Subtype Discovery"
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Questions and Submissions

The schedule of dissertation defenses in the Department of Biostatistics is maintained by:

Renee Valenti

412-624-3023

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